With Lo Celso and Bergwijn seemingly both missing out, it is imperative that Lamela and Ndombele both start. There isn't going to be enough creativity from the likes of Winks and Lucas to help the team get off to the fast start it needs. Reguilon also needs to start. If Mourinho goes with Lucas, Winks and Davies instead of Lamela, Ndombele, and Reguilon, we will likely fall behind and need a second half goal to salvage a draw. He has to start putting his most talented players on the pitch together, who also happen to be the ones who have been in great form this season (specifically the three aforementioned names who shined against Chelsea).